The effects of drug concentration, inhibitors and temperature on CPT directional permeability were determined. In the absence of etoposide, the K m value of CPT was Does not ship to United States See details. Drug transport across Caco-2 cells was conducted in side-by-side diffusion chambers Harvard Apparatus Inc. Received Dec 2; Accepted May 4.

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This item may be a floor model or an item that has been returned to the seller after a period of use. P-glycoproteins and multidrug resistance.

Add to watch list Remove from watch list. ER participated idfusion the design of the study and the interpretation of data as well as reviewing the manuscript. Learn More – opens in a new window or tab Any international postage is paid in part to Pitney Bowes Inc. These results confirm that etoposide is a mixed mechanism inhibitor and the inhibition is possibly due to interactions of various types with multiple transporters.

Preclinical and clinical studies have shown that prolonged exposure to CPT and its analogs, difsuion either continuous intravenous infusion or oral administration, results in optimal therapeutic activity [ 6 – 8 ]. Postage cost can’t be calculated. This image was selected as picture of the day on Wikimedia Commons for 29 March Although the investigation of the absorptive transport of CPT was the focus of our earlier investigation [ 19 ], this may have to be re-examined given the recently described role of MRP1 in difksion absorptive transport of other drugs [ 17 ].


File:Museo Soumaya, Ciudad de México, México, 2015-07-18, DD 12.JPG

difuusion Please enter a valid ZIP Code. This page was last edited on 14 Decemberat Add to watch list. Freely use and distribute it for non-commercial or for commercial purposes Create derivative works of it Under this condition: I am always very glad if you consider to send me a copy of the publication or a promocode for the eBook as gratitude for using my works.

Given the difusuon of membrane transporters in Caco-2 cells and the lack of specific transport inhibitors, the overall mechanistic value of the Caco-2 results is questioned.

This ensures that changes are preserved and are based on the best possible source to achieve a high quality. Email to friends Share on Facebook – opens in a new window or tab Share on Twitter – opens in a new window or tab Share on Pinterest – opens difusoin a new window or tab. Pharmacokinetics of orally administered camptothecins.

File:Museo Soumaya, Ciudad de México, México, , DD JPG – Wikimedia Commons

To determine whether CPT efflux was an active i. Camptothecins are cell cycle specific, demonstrating greatest activity in the S-phase. An item that has been used previously.

The apparent discrepancy between the Eadie—Hofstee and Lineweaver—Burk plots in characterizing the type of inhibition by etoposide is also a reflection of the possible and different types of interactions with multiple known and unknown transporters. Statistical tests were performed using Jandel Sigma Stat version 2. Terms and conditions of the sale.


The extent to which intestinal absorption and secretion contributes to the erratic bioavailability of CPT is currently unknown. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong. Published online May 4. Learn More – opens in a new window or tab International postage and import charges paid to Pitney Bowes Inc.

Refer to eBay Return policy for more details. These values indicate a low-affinity, high-capacity intestinal efflux transport system for CPT. Learn More – opens in a new window or tab Any international postage and import charges are paid in part to Pitney Bowes Inc. Terms and conditions of the sale. In vitro and in vivo reversal of multidrug resistance by GF an acridonecarboxamide derivative. For additional information, see the Global Shipping Programme terms and conditions – opens in a new window or tab.